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Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Precision Medicine for OCD - Biobehavioral Tracking of Transcranial Magnetic Stimulation (TMS) With Exposure and Response Prevention (ERP) for Refractory OCD
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria. * Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks. * Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions) * Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD * Willing to maintain psychotropic medication levels throughout the 16 weeks of the study Exclusion Criteria: * Primary psychiatric diagnosis other than OCD * Active substance use disorder * Active suicidality * Active psychosis * History of seizures * Severe neurological impairment * Pregnant or planning to become pregnant * Received a prior rTMS course
About the study
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.
What is being tested
- Repetitive Transcranial Magnetic Stimulation (rTMS) (device)
- Supportive Therapy (ST) (behavioral)
- Exposure and Response Prevention (ERP) Therapy (behavioral)
Sponsor: Adam Frank · Participants: 48 · Started: Nov 10, 2025
Contact the study team
- USC Frank OCD Lab · Phone: 323-442-3632
- Emma Garland, BA · Phone: 213-821-3120
Official record on ClinicalTrials.gov — NCT07146438
Locations in the U.S.
| California | University of Southern California Health Sciences Campus, Los Angeles |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.