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Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening

RecruitingObservational study

Who can join

Ages 8 to 45 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Body weight ≥43 kg
* Presence of at least one islet autoantibody and/or≥ diagnosis of clinical T1D within 100 days.
* Documentation of the presence at least 1 islet autoantibody
* If participants meet ADA diagnostic criteria for Stage 3 type 1 diabetes, they will be eligible if the enrollment occurs within 100 days from the diagnosis and are at least 12 years old.
* Participants must be in good general health without other acute (e.g. infectious disease) febrile or chronic illnesses (e.g. uncontrolled asthma requiring high steroid doses, chronic arthritis) that in the judgment of the investigator could jeopardize participant safety or interfere with the study,
* Ability to give consent/assent
* Able to understand written and spoken English

Exclusion Criteria:

* Currently pregnant or becomes pregnant during the study
* Participants on sodium glucose cotransporter inhibitors (SGLTi).
* Donated blood in the past 8 weeks.

About the study

This study aims at quantifying the accuracy of a self-administered fingerstick based glucose tolerance test (GTT@Home) respect to the gold-standard in-clinic venous plasma measures during the oral glucose tolerance test (OGTT) across a wide range of glycemic values in people at risk for clinical type 1 diabetes (T1D) (carriers of at least one islet autoantibody) or with new onset Stage 3 T1D within 100 days from the diagnosis.

What is being tested

Sponsor: Yale University · Participants: 60 · Started: Aug 26, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07155252

Locations in the U.S.

ConnecticutYale University Pediatric and Adult Diabetes Clinic, New Haven

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.