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Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

RecruitingPhase 1

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Ability to provide consent and comply with study procedures
* Diagnostic and Statistical Manual of Mental Disorders criteria for OUD
* Undergoing medication treatment for OUD. Participants may have current comorbid drug use, but primary diagnosis must be OUD
* Intention to remain in the study until intervention completion.

Exclusion Criteria:

* Any medical condition with neurological sequelae
* Head injury resulting in skull fracture or loss of consciousness of \>30 minutes
* Any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia)
* Any psychotic disorder (participants with other treated and stable psychiatric disorders will be included)
* Presence of a condition that would render study measures impossible to administer or interpret
* Age younger than 18
* Primary current substance use disorder on a substance other than opioids except for caffeine or nicotine
* In treatment instead of jail
* Pregnancy
* Disrespectful behavior towards the investigators and staff.

About the study

The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).

What is being tested

Sponsor: University of Minnesota · Participants: 40 · Started: Feb 4, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07158853

Locations in the U.S.

MinnesotaUniversity of Minnesota, Minneapolis

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.