Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

Recruiting

Who can join

Ages 10 to 17 · All sexes

Full eligibility criteria

Inclusion Criteria:

* Adolescent Participants

  * 10-17-year-old survivors of childhood cancer or those who received cancer directed therapies (e.g., Langerhan's Histiocytosis)
  * At least one-year post treatment completion
  * Pain present for 3 months or longer
  * Pain interfering with at least one area of daily functioning
* Parent/Caregiver Participants

  * ≥ 18 years of age
  * Legally authorized to provide informed consent for the adolescent participant

Exclusion Criteria:

* Adolescent Participants

  * Serious comorbid psychiatric condition
  * Current substance abuse as determined by the Substance Use Screening Questionnaire
  * History of development delay or significant cognitive impairment

    * Note: A participant who completed the feasibility study (ADAPTED) cannot participate in the subsequent clinical trial (ADAPTED2)
* Parent/Caregiver Participants

  * Not fluent in English or Spanish
  * Unable to provide consent for own participation or for the participation of the adolescent participant

About the study

The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in adolescent survivors of pediatric cancer.

This randomized study led by St. Jude Children's Research Hospital will involve 228 participants (114 adolescent survivors and 114 caregivers) across four U.S. hospitals. Outcomes include pain reduction, improved function, and the role of social determinants of health. Assessments occur at baseline, post-treatment, and 3-month follow-up.

What is being tested

Cognitive Behavioral Therapy (CBT) (behavioral)
Education (behavioral)
Questionnaires (other)

Sponsor: St. Jude Children's Research Hospital · Participants: 116 · Started: Sep 5, 2025

Contact the study team

Tara Brinkman, PhD · Phone: 888-226-4343
Tara Brinkman · Phone: 8662785833

Official record on ClinicalTrials.gov — NCT07160621

Locations in the U.S.

Tennessee

St. Jude Children's Research Hospital, Memphis

Conditions

Chronic Pain

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.