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Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

R00 Full Factorial Trial: Optimizing ASCENT

Who can join

Ages 15 to 39 · All sexes

Inclusion Criteria:

* Age at enrollment (adolescents 15-17, emerging adults 18-25, young adults 26-39)
* Age at diagnosis (adolescents 12-17, emerging adults 15-25, young adults 15-39)
* Time since completion of treatment: 1 month to 5 years
* Language: Fluent in English (spoken and written)
* Technology: Own smart phone with data plan

Exclusion Criteria:

* Mental Health: Current diagnosis of severe or persistent mental illness
* Suicidality: Severe suicidal ideation (including plan and intent)

About the study

Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes one psychoeducation component and four components that are based on evidence-based interventions for depression. The goal of this study is to test which component or combination of components meaningfully contribute to improvements in depressive symptoms among AYAs.

What is being tested

• AYA Survivors Coping and Emotional Needs Toolkit (ASCENT) (behavioral)

Sponsor: East Carolina University · Participants: 208 · Started: Oct 25, 2025

Contact the study team

• AnneMarie Coffey, BS · Phone: 252-328-6244

Official record on ClinicalTrials.gov — NCT07173205

Locations in the U.S.

Conditions

• Depression
• Cancer (all types)

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.