Quantitative Ultrasound(DeepUSFF) vs MRI-PDFF for Liver Fat Assessment in MASLD

Inclusion Criteria:

* Patients with clinically suspected MASLD based on abnormal ultrasound or liver function tests requiring liver ultrasound or MRI examination
* BMI ≥25 kg/m² or waist circumference \>90 cm (male) or \>80 cm (female), suggesting high likelihood of fatty liver disease
* Living liver transplant donors requiring preoperative liver ultrasound or MRI examination
* Age ≥18 years
* Understanding and signing informed consent

Exclusion Criteria:

* Significant alcohol consumption in the past 2 years:

Male: ≥30-60g/day average alcohol intake Female: ≥20-50g/day average alcohol intake

-Chronic liver disease:

Histological diagnosis of chronic liver disease HBsAg positive Anti-HCV positive Other suspected chronic liver diseases

-Liver failure:

Serum albumin \<3.2 g/dL INR \>1.3 Direct bilirubin \>1.3 mg/dL

* History of esophageal varices, ascites, hepatic encephalopathy, or acute biliary obstruction
* History of liver cancer diagnosis or treatment
* History of liver surgery
* Pregnancy
* Inability to obtain adequate liver ultrasound imaging:

Patient cooperation impossible Inadequate image acquisition as determined by investigator

-Inability to obtain adequate liver MRI imaging: Patient cooperation impossible Severe obesity preventing MRI examination MRI contraindications (cardiac pacemaker, etc.) Other factors preventing adequate imaging as determined by investigator