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AI-Guided Left Bundle Branch Area Pacing
Recruiting
A Pilot Study Assessing Outcomes Of Artificial Intelligence-Guided Left Bundle Branch Area Pacing For Cardiac Resynchronization In Heart Failure
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria * Age: 18 years or older. * Left Ventricular Ejection Fraction (LVEF): \<50% within 6 months prior to enrollment. * QRS Duration: Resting QRS duration ≥ 130 ms on ECG OR anticipated right ventricular pacing \> 40% OR device in place with right ventricular pacing \> 40% within 6 months prior to enrollment. * Medical Therapy: Optimized on guideline-directed medical therapy for heart failure. * AI-ECG probability of low LVEF: \>0.5 Exclusion Criteria * Age less than 18 years old * Inability to follow-up * Pregnancy
About the study
The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.
What is being tested
- AI-assisted Left Bundle Branch Area Pacing (device)
- Left Bundle Branch Area Pacing (procedure)
Sponsor: Mayo Clinic · Participants: 224 · Started: Jan 23, 2026
Contact the study team
- Joseph Abdel Messih · Phone: 507-422-3967
Official record on ClinicalTrials.gov — NCT07206602
Locations in the U.S.
| Minnesota | Mayo Clinic in Rochester, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.