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Behavioral Safety and Fentanyl Education: BSAFE

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Aged 18 years or older,
2. Reports intentional cocaine or methamphetamine use ≥7 of past 30 days,
3. Urine positive for cocaine or methamphetamine and negative for opioids/fentanyl prior to enrollment
4. Be able to provide the names of at least 2 persons who can consistently locate their whereabouts.
5. Reports at least one suspected unintentional fentanyl use event, including unexpected sedation or unexpected fentanyl-positive bodily fluid drug testing result.

Exclusion Criteria:

1. Reports past 30-day intentional use of any opioid or ongoing use of an opioid antagonist (e.g., naltrexone)
2. Intends to leave area in coming year,
3. Unable to communicate in English or Spanish,
4. Any other condition that, in the PI's judgment, interferes with safe study participation or adherence to study procedures.

About the study

BSAFE is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among people who use stimulants who may have unintentional fentanyl use (UFU). It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of BSAFE vs attention-control.

What is being tested

• BSAFE Intervention (behavioral)
• Attention control (behavioral)

Sponsor: San Francisco Department of Public Health · Participants: 160 · Started: Aug 11, 2026

Contact the study team

• Phillip O Coffin, MD, MIA · Phone: (628) 217-6282
• Xochitl Luna Marti, MPH · Phone: (628) 217-6235

Official record on ClinicalTrials.gov — NCT07219082

Locations in the U.S.

Conditions

• Opioid Overdose

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.