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Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
Who can join
Ages 18 to 72 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adult ≥ 18 years of age * Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision) Exclusion Criteria: * \<18 or \>72 Years of age * Body Mass Index \>40 * Known allergy to methadone * Pregnant females * Non-English-speaking patients
About the study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.
What is being tested
- Methadone (drug)
- Placebo (drug)
Sponsor: The Cleveland Clinic · Participants: 120 · Started: Nov 15, 2025
Contact the study team
- Stephanie Stoianoff, MBA · Phone: 12164440231
- Sandra Durbin, CLPN, CCRP · Phone: 216-269-4073
Official record on ClinicalTrials.gov — NCT07222072
Locations in the U.S.
| Ohio | Cleveland Clinic, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.