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Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

Postpartum Education Via Artificial Intelligence for Recovery and Loneliness (PEARL): A Randomized Controlled Trial

Who can join

Ages 18 and older · Women

Inclusion Criteria:

1. Has the capacity to provide informed consent
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Postpartum persons, aged \>18 years old
4. Primiparous
5. Vaginal or cesarean delivery
6. English Speaking
7. Internet access and proficiency of internet access
8. Access to a smartphone
9. Postpartum 2-6 weeks

Exclusion Criteria:

1. Multiparous
2. Major neonatal anomaly
3. Delivery \< 34 weeks gestational age
4. Intrauterine fetal demise (IUFD)
5. Enrollment in any interfering studies
6. Unanticipated NICU admission
7. Discharge home without live baby
8. Surrogates/gestational carrier
9. Birthing individuals with baby placed for adoption
10. Currently pregnant
11. Psychiatric history requiring psychiatric hospitalization prior to delivery
12. Other psychiatric conditions needing immediate attention and intervention as determined by study team and/or treatment team

About the study

The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth.

The main questions this study aims to answer are:

* Does using the chatbot improve postpartum pelvic floor health knowledge? * Does using the chatbot help reduce feelings of loneliness during the postpartum period? * Does using the chatbot impact pelvic floor symptoms?

Researchers will compare standard postpartum care to standard care plus the chatbot.

Participants will:

Be assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot.

If in the chatbot group, participants will receive education and support via the chatbot over a 4-week period.

Both groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress.

The chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.

What is being tested

• Generative artificial intelligence (genAI) postpartum chatbot (other)
• Standard of Care (SOC) (other)

Sponsor: University of California, San Diego · Participants: 130 · Started: Jan 8, 2026

Contact the study team

• Alexandra C Nutaitis, DO · Phone: 858-657-7344
• Cecile Ferrando, MD, MPH · Phone: (858) 657-1238

Official record on ClinicalTrials.gov — NCT07223736

Locations in the U.S.

Conditions

• Pelvic Floor Disorders
• Depression

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.