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Hippocampal Oscillations During Exploration
Human Hippocampal Oscillations During Visuomotor Exploration
Who can join
Ages 18 to 70 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: All subjects: * Adults (18-70 years) * Able to provide informed consent Aim 1: Surgical epilepsy patients' inclusion criteria * Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery * MMSE\>=24 Aim 2: RNS patients Inclusion criteria * Implanted RNS device with at least one hippocampal depth electrode * At least 5 months post-implantation to avoid the post-implant effect * Have a relatively low number of seizures, defined as \<1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month * Able to walk and wear research equipment without assistance * MMSE\>=24 Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance Exclusion Criteria: RNS patients, Aim 2: • Any generalized tonic-clonic seizure within the last week All subjects: * Legally blind * Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing * Unable to give informed consent * Pregnancy
About the study
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
What is being tested
- Visual Exploration (other)
- Ambulatory Exploration (other)
Sponsor: NYU Langone Health · Participants: 56 · Started: Feb 25, 2026
Contact the study team
- Anli Liu, MD, MA · Phone: (929) 455-2323
- Ayelet Rosenberg · Phone: (646) 558-0893
Official record on ClinicalTrials.gov — NCT07224191
Locations in the U.S.
| New York | NYU Langone Health, New York |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.