Home › Colorectal Cancer › NCT07224724
Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Adults (≥18 years old) * Histologically- or cytologically-confirmed colorectal cancer that is metastatic * Availability of pre-treatment plasma samples * Written informed consent provided * Sufficient clinical and imaging data to determine presence/absence of extrahepatic metastasis Exclusion Criteria: * Prior malignancies within 5 years * Poor sample quality or hemolysis * Inability to provide informed consent
About the study
Colorectal cancer is the third most common malignancy worldwide, and prognosis largely depends on how effectively metastatic disease is managed. The liver is the most frequent and prognostically important site of metastasis, and patients responding well to chemotherapy may become candidates for curative hepatic resection. However, the presence of extrahepatic metastasis (EHM) critically influences treatment eligibility and survival. Although clinical scores such as the Fong and Beppu systems include EHM as a determinant, its detection by imaging remains limited, especially for small or occult lesions. Accurate identification of EHM is also essential when considering liver transplantation for unresectable colorectal liver metastases (CRLM), where EHM remains an exclusion criterion.
The EXELION Study aims to develop a non-invasive diagnostic model using serum exosomal microRNAs (miRNAs) to detect both hepatic and extrahepatic metastases in patients with CRLM. By integrating circulating miRNA profiling with machine learning-based analysis, this study seeks to supplement imaging diagnostics, improve treatment stratification, and enhance clinical decision-making for metastatic colorectal cancer.
What is being tested
- EXELION (other)
Sponsor: City of Hope Medical Center · Participants: 500 · Started: Jun 1, 2024
Contact the study team
- Ajay Goel, PhD · Phone: 626-218-3452
Official record on ClinicalTrials.gov — NCT07224724
Locations in the U.S.
| California | City of Hope Medical Center, Duarte |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.