Home › Mild Cognitive Impairment › NCT07225400

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

Who can join

Ages 65 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 65 and older with amnestic mild cognitive impairment (aMCI);
* Can speak English;
* Agrees to MoBI recording;
* Normal or corrected-to-normal vision/audition;
* Able to walk unassisted for 10 minutes;
* Plan to be in the area for next year

Exclusion Criteria:

* Dementia (Memory Impairment/AD8 screen);
* Medical conditions that affect participation such as vertigo and neck pain;
* Hospitalization in the past six months or plans for surgery affecting participation in the next four months;
* Mobility limitations solely due to musculoskeletal limitation or pain;
* Terminal illness with life expectancy less than 12 months;
* Presence of clinical disorders that overtly alter attention like delirium;
* Active psychoses or psychiatric symptoms;
* Living in nursing home;
* Participation in intervention trial;
* Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury;
* Pregnant women

About the study

The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities.

Main Aims:

1. To determine whether at least 70% of older adults enrolled in the study can complete twenty-four 50-minute training sessions over a 4-month period. 2. To assess whether combining virtual reality with EEG recordings can be used to measure brain activation and changes in brain activation associated with spatial navigation learning.

Participants will:

1. Walk in an open, unobstructed space while wearing VR goggles. 2. Explore up to fifty different virtual mazes in sequence and attempt to find their way through each one.

What is being tested

• Spatial Navigation training (behavioral)

Sponsor: Albert Einstein College of Medicine · Participants: 30 · Started: Sep 15, 2026

Contact the study team

• Pierfilippo De Sanctis, PhD · Phone: 718-862-1828
• Maya Hoff, BS · Phone: 7188397650

Official record on ClinicalTrials.gov — NCT07225400

Locations in the U.S.

Conditions

• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.