Home › Pain After Surgery › NCT07226076
Methadone in TKA for Post-op Pain and Opioid Reduction
Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
Who can join
Ages 18 to 75 · All sexes
Full eligibility criteria
Inclusion * Ages 18-75 years of age * Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia Exclusion * Allergy to methadone or mepivacaine * Severe liver disease defined as Child's Pugh Class C * End stage renal disease requiring dialysis * Known diagnosis of prolonged QT syndrome * Currently pregnant * Unable to provide written, informed consent * Non-English speaking
About the study
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
What is being tested
- Methadone Hydrochloride (drug)
Sponsor: Medical University of South Carolina · Participants: 162 · Started: Jan 8, 2026
Contact the study team
- Haley Nitchie, MHA · Phone: 843-792-1869
Official record on ClinicalTrials.gov — NCT07226076
Locations in the U.S.
| South Carolina | Medical University of South Carolina, Charleston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.