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Targeted Accelerated TMS for Post-Traumatic Stress Disorder

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria

* Age 18-65
* DSM-5 diagnosis of PTSD per PTSD Checklist for DSM-5 (CAPS-5)
* At least moderate symptoms of PTSD per PCL-5 (≥21)
* English proficiency sufficient to understand risks/benefits
* No new medications or medication increases before, during, or after aTMS
* Primary clinician (e.g. psychiatrist, therapist, psychologist, APRN, PA, etc.) responsible for psychiatric care before, during, and after the trial
* Agreement to lifestyle considerations:
* Abstain from becoming pregnant from screening to one-month after treatment (the MRI visit)
* Continue usual intake patterns of caffeine- or xanthine-containing products (e.g. coffee, tea, soft drinks, chocolate) throughout treatment
* No changes to routine intake of alcohol, tobacco, and recreational drugs if patients are using them at baseline for at least 24 hours before the start of each MRI and TMS session

About the study

Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited efficacy and high dropout rates, highlighting the need for novel, rapidly effective interventions.

Transcranial magnetic stimulation (TMS) has been well established for treatment-resistant depression (TRD). Traditional TMS, which involves 6 to 7 weeks of daily, weekday scalp-targeted treatment, shows open-label response and remission rates of 58.1% and 30%, respectively. However, such protocols may be impractical for military personnel with limited medical leave. A new form of accelerated TMS (aTMS) that involves 10 imaging-guided treatments per day for 5 consecutive days has demonstrated substantial antidepressant benefits within days and response rates of 69% at 1-month follow-up. This protocol has not been tested for PTSD, in part because there was no causally informed brain circuit target. In this study, the investigators will test aTMS for PTSD using a novel PTSD circuit that the investigators have derived.

What is being tested

• Transcranial Magnetic Stimulation (procedure)

Sponsor: Brigham and Women's Hospital · Participants: 40 · Started: Dec 15, 2025

Contact the study team

• Interventional Psychiatry Research Group · Phone: 6175253526

Official record on ClinicalTrials.gov — NCT07245641

Locations in the U.S.

Conditions

• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.