Promoting Recovery After Brain Injury Using Focused Ultrasound
Who can join
Ages 18 to 79 · All sexes
Full eligibility criteria
Inclusion Criteria: * Brain injury resulting in DoC diagnosis, following international guidelines * At least 18 years of age * Legally authorized representative (surrogate) available to consent Exclusion Criteria: * History of neurological disorder other than the brain injury * Metal implant or other condition precluding MRI * Manifest continuous spontaneous movement (which would prevent safe/successful MRI) * Participation in concurrent therapeutic study * Pregnancy
About the study
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
What is being tested
- Low-intensity focused ultrasound (device)
Sponsor: Massachusetts General Hospital · Participants: 36 · Started: May 26, 2026
Contact the study team
- Michael Young, MD, MPhil · Phone: 410-808-1196
- Jason Lew, DO · Phone: 617-724-9247
Official record on ClinicalTrials.gov — NCT07277309
Locations in the U.S.
| Massachusetts | Massachusetts General Hospital (The General Hospital Corp.), Boston Spaulding Rehabilitation Hospital Corporation, Inc., Cambridge |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.