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Cannabidiol and Alcohol Use Disorder Phenotypes

Effects of Full-spectrum Cannabidiol on Alcohol Consumption and Alcohol Use Disorder Phenotypes: Implications for Precision Medicine

Who can join

Ages 21 to 65 · All sexes

Inclusion Criteria:

1. Age 21-65
2. Have used CBD and cannabis at least once in the last year
3. Regularly drink alcohol
4. Able to provide informed consent and attend in-person study visits

Exclusion Criteria:

1. Current use of medications known to have major interaction with Epidiolex, Marinol, or alcohol
2. Current use of antiepileptic medication or any psychotropic medication besides antidepressants
3. Pregnant, nursing, or planning a pregnancy
4. Medical conditions that contraindicates the use of CBD or alcohol
5. Current medical conditions that may require intensive care during the study period

Not everyone will qualify to be in the study. Other inclusion and exclusion criteria will be evaluated by the study team.

About the study

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

What is being tested

• Full-Spectrum Cannabidiol (CBD) (drug)
• Broad-Spectrum Cannabidiol (CBD) (drug)
• Placebo (drug)

Sponsor: University of Colorado, Denver · Participants: 150 · Started: Apr 21, 2026

Contact the study team

• Hollis C Karoly, PhD · Phone: 303-724-7179
• Landon Tomb, M.S. · Phone: 225-244-3429

Official record on ClinicalTrials.gov — NCT07279558

Locations in the U.S.

Conditions

• Alcohol Use Disorder (AUD)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.