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A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

Vagus Nerve Stimulation (VNS) Paired With Mobility Training For Gait Recovery After Chronic Ischemic Stroke With Integration Of Biomarker Assessment

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥ 18 years
* Ischemic stroke ≥6 months prior to enrollment.
* Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test
* Provision of informed consent

Exclusion Criteria:

* Intracerebral Hemorrhage
* Active or prior psychosis or substance abuse within two years.
* Pre-stroke modified Rankin Scale (mRS) 3-5.
* Unable to participate in in-clinic rehabilitation.
* Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma.

About the study

The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.

What is being tested

• Vagus nerve stimulation (VNS) paired with mobility training (other)

Sponsor: Mayo Clinic · Participants: 20 · Started: Dec 3, 2025

Contact the study team

• Neurosurgery Research Team · Phone: 507-538-6563

Official record on ClinicalTrials.gov — NCT07291024

Locations in the U.S.

Conditions

• Ischemic Stroke

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.