Home › Post-Traumatic Stress Disorder › NCT07334418

Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

EAGLET-CS Pilot: Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics).

Exclusion Criteria:

* We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.

About the study

Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after pregnancy. Currently, the two main options for treating this pain are general anesthesia (full medically induced unconsciousness) and using intravenous medications to reduce the pain and decrease anxiety. The EAGLET-CS Pilot is a pilot randomized trial that will test the feasibility of comparing the impact of these two options for preventing PTSD in a rigorous way for those patients who experience pain during their cesarean section after the baby is out.

What is being tested

• General anesthetic (other)
• Intravenous anesthetic (other)

Sponsor: University of Pennsylvania · Participants: 600 · Started: Apr 6, 2026

Contact the study team

• Mark Neuman, MD · Phone: 215-746-7468

Official record on ClinicalTrials.gov — NCT07334418

Locations in the U.S.

Conditions

• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.