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Electrophysiology-based DBS Programming for PD

Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease

Who can join

Ages 21 to 89 · All sexes

Inclusion Criteria:

* Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD
* DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms
* Ability to give informed consent for the study
* Willingness to do this study at the time of the initial programming session
* Age 21 to 89 years old

Exclusion Criteria:

* Inability to comply with the study protocol
* Atypical Parkinsonism
* Any personality or mood symptoms that study personnel believe will interfere with the study requirements

About the study

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

What is being tested

• Clinician-based DBS programming (device)
• Maximum Beta power-based DBS programming (device)
• Broad-band electrophysiology-based DBS programming (device)

Sponsor: University of Florida · Participants: 30 · Started: Jan 15, 2026

Contact the study team

• Joshua Wong, MD · Phone: 352-294-5400

Official record on ClinicalTrials.gov — NCT07348705

Locations in the U.S.

Conditions

• Parkinson's Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.