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Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Recruiting
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)
Who can join
Ages 18 and older · Women
Full eligibility criteria
Inclusion Criteria: * Postpartum women aged 18 years or older * Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features) * Taking Nifedipine 60 mg every 12 hours for blood pressure control * Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication * English speaking Exclusion Criteria: * Taking ≥2 antihypertensive agents during pregnancy * Heart block * Heart rate \<60 or \>120 beats per minute * Heart failure * Creatinine \>1.5 mg/dL * Renal artery stenosis * Active connective tissue disease * Cerebrovascular accident * Failed treatment or contraindications to nifedipine, enalapril or labetalol
About the study
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
What is being tested
- Nifedipine and Enalapril (drug)
- Nifedipine and Labetalol (drug)
Sponsor: The Cleveland Clinic · Participants: 200 · Started: Mar 10, 2026
Contact the study team
- Amol Malshe, M.D. · Phone: 216 903-9646
Official record on ClinicalTrials.gov — NCT07363343
Locations in the U.S.
| Ohio | Cleveland Clinic, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.