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Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study

Recruiting

Feasibility, Preliminary Efficacy, and User Perspective Usability of Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study

Who can join

Ages 18 to 100 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Aged over 18 years
* Confirmed diagnosis of RRMS according to the McDonald criteria (33)
* No MS relapse or exacerbation within the past 6 months (ensuring stability of symptoms)
* Self-report on clinical evidence of UEx impairment (including reduced arm/hand function, muscle weakness, spasticity, or pain).
* Stable on MS treatment for at least four weeks before recruitment, with no plans to initiate new treatments (participants may continue current treatments during the study)
* Agree and are able to use the FVT device after training.
* Sufficient proficiency in English to participate in interviews and follow instructions
* Able to visit the laboratory for assessments
* Able to provide written informed consent

Exclusion Criteria:

* Evidence of cognitive impairment that could interfere with following instructions (Mini-Montreal Cognitive Assessment score (Mini-MoCA) \< 12)
* Comorbid neurological or psychiatric conditions affecting the UEx (including stroke and severe carpal tunnel syndrome) that would confound results or make FVT unsafe
* Unstable cardiac disease or any major medical illness that would preclude participation
* Any known contraindications to vibration therapy (pregnancy, acute deep vein thrombosis, severe osteoporosis, chronic migraines, epilepsy, active malignancy in the target area, unstable cardiac disease, or an implanted pacemaker without clearance)

About the study

This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people with multiple sclerosis (MS). Fifteen adults with relapsing-remitting MS (PRMS) and self-reported UEx impairments will participate in a 4-week FVT program using MyovoltTM wearable FVT devices applied to arm muscles.

What is being tested

Sponsor: University of Florida · Participants: 15 · Started: Mar 4, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07376772

Locations in the U.S.

FloridaNorman Fixel Institute for Neurological Diseases, Gainesville
University of Florida, Gainesville

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.