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Zesty Exercise System for Therapeutic Engagement

Who can join

Ages 40 and older · All sexes

Inclusion Criteria:

-Older adults with mild to moderate PD.

Exclusion Criteria:

* Acute medical illness requiring hospitalization;
* Under 40 years old;
* Uncontrolled congestive heart failure;
* History of stroke in the past three years;
* Inability to perform study procedures;
* Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity);
* On medications that could adversely affect cognition, e.g.: antipsychotics, opioids, stimulants, chemotherapy;
* Psychotic disorders;
* Confounding neurologic conditions (e.g., active central nervous system opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae);
* Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation;
* Hohn \& Yahr \> 3
* MoCA \<17

About the study

This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The study will assess feasibility, retention, safety, acceptability, and tolerability of remotely monitored ZEST-E and will measure changes in functional performance using the Standing Forward Reach test and the 30-Second Chair Stand test. These outcomes reflect range of motion and lower-body strength targeted by the exercise program.

What is being tested

• ZEST-E Robot-Assisted Exercise Program (device)

Sponsor: Emory University · Participants: 46 · Started: Mar 16, 2026

Contact the study team

• Madeleine Hackney, PhD · Phone: 314-412-4852

Official record on ClinicalTrials.gov — NCT07382674

Locations in the U.S.

Conditions

• Parkinson's Disease

From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.