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Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy

Instillation of Bupivacaine With Epinephrine Over Diaphragm to Reduce Postoperative Shoulder Pain Following Benign Gynecologic Laparoscopic Surgery: A Randomized Control Trial

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* Provide a signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study
* 8 years of age or older
* Undergoing laparoscopic surgery at Cedars-Sinai Medical Center with a surgeon in the Minimally Invasive Gynecologic Surgery division.

Exclusion Criteria:

* Pregnancy
* Urgent/non-scheduled surgery
* Scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure)
* Baseline shoulder pain
* Baseline opioid use
* Baseline of chronic pain syndrome
* Conversion to open surgery
* Allergy or intolerance to bupivacaine, lidocaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen
* Planned post-operative admission

About the study

Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after surgery is well established. However, there have been no studies on sprayed bupivacaine over the diaphragm to reduce shoulder pain in laparoscopic surgery. The purpose of the study is to evaluate if sprayed infra-diaphragmatic bupivacaine compared to placebo (saline) will improve postoperative shoulder pain in patients undergoing benign laparoscopic gynecologic surgery. The entire study will be conducted at Cedar Sinai Medical Center.

What is being tested

• Instillation of Bupivacaine with epinephrine over the diaphragm (drug)

Sponsor: Cedars-Sinai Medical Center · Participants: 100 · Started: Mar 2, 2026

Contact the study team

• Ogechukwu Ezike, MD · Phone: 3473371181

Official record on ClinicalTrials.gov — NCT07400146

Locations in the U.S.

Conditions

• Pain After Surgery
• Shoulder Pain

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.