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Gait and Bone Health in SMA

Identification of Gait-related Digital Biomarkers of Bone Health in Spinal Muscular Atrophy

Who can join

Ages 8 to 50 · All sexes

Inclusion Criteria:

* Confirmed diagnosis of 5qSMA
* Between 8 and 50 years of age
* Able to walk 10 meters without support or an assistive device
* All participants who meet the inclusion criteria regardless of treatment status will be included, including those on adjuvant therapies, whether investigational or approved

Exclusion Criteria:

* Injury or surgery within previous 3 months that would impact ability to perform in-clinic gait assessments
* Unwilling or unable to comply with all study procedures
* Age less than 8 or over 50 years

About the study

The objective of this study is to understand how spatiotemporal and kinetic gait parameters are associated with bone health in pwSMA who are receiving DMT. We hypothesize that gait parameters are associated with BMD and can determine fracture risk in pwSMA. This is an observational study that involves one in-clinic visit (approximately 3 hours) with remote follow-up visits (approximately 15 minutes) every 3 months for 1 year to collect fracture and medical history. Each of the assessments included in this study are non-interventional and are not intended as a treatment nor are they at the level of standard of care.

Sponsor: Jacqueline Montes · Participants: 22 · Started: Mar 5, 2026

Contact the study team

• Cara Kanner, PT, DPT, EdD · Phone: 516-581-8150

Official record on ClinicalTrials.gov — NCT07400198

Locations in the U.S.

Conditions

• Spinal Muscular Atrophy
• Fractures

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.