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Spinal Muscular Atrophy clinical trials recruiting in the U.S.

23 studies for Spinal Muscular Atrophy are recruiting participants at sites across the United States.

Spinal muscular atrophy (SMA) attacks nerve cells in the spinal cord, weakening voluntary muscles. Read about the genetics, types, and what may help.

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Recently updated studies

A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

RecruitingPhase 2
Up to age 2 · All sexes · Updated Sep 14, 2026 · NCT07047144

A Registry of Cases of Spinal Muscular Atrophy

RecruitingObservational study
All ages · All sexes · Updated Sep 8, 2026 · NCT07805278

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

Recruiting
Ages 18 to 80 · All sexes · Updated Sep 2, 2026 · NCT07521930

Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

Recruiting
Ages 3 and older · All sexes · Updated Aug 19, 2026 · NCT05866419

Clinical Procedures to Support Research in ALS

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03489278

ALS/MND Natural History Study Data Repository

RecruitingObservational study
Ages 18 to 90 · All sexes · Updated May 20, 2026 · NCT05966038

Characterizing Perceived Physical Fatigability in Nusinersen-treated SMA

RecruitingObservational study
Ages 12 and older · All sexes · Updated May 14, 2026 · NCT06955897

Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders

RecruitingObservational studyHealthy volunteers welcome
Ages 5 and older · All sexes · Updated Apr 9, 2026 · NCT06839469

HABIT-ILE + FST in Children With SMA: Preliminary Effectiveness

Recruiting
Ages 5 to 17 · All sexes · Updated Mar 23, 2026 · NCT07488338

Gait and Bone Health in SMA

RecruitingObservational study
Ages 8 to 50 · All sexes · Updated Mar 18, 2026 · NCT07400198

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Recruiting
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT07478172

Diagnostic Journey, Patient Experience, and Disparities in the Treatment of Spinal Muscular Atrophy (SMA) in the MedStar Health System

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT07223489

Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

RecruitingObservational study
All ages · All sexes · Updated Jan 31, 2025 · NCT04174157

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.