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Stimulation of External Carotid Artery Circulation
Feasibility and Safety of Endovascular Bipolar Stimulation of the Middle Meningeal Artery for Refractory Headaches (MMA-Stim)
Who can join
Ages 18 to 100 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥18 * Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion. * Subject has provided informed consent. Exclusion Criteria: * Known allergies to lidocaine * Seizure disorder, history of seizures, or increased seizure susceptibility * Intracranial vascular malformations or dural AVF * Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk * Previous MMA intervention or craniotomy that could result in MMA occlusion * Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator) * Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI) * Severe autonomic dysfunction * Active systemic infection * Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent)
About the study
This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches.
The goal of the study is to determine whether this approach could improve headache symptoms and overall outcomes for people with migraines.
What is being tested
- Cadwell Cascade 32 PRO (device)
Sponsor: The University of Texas Medical Branch, Galveston · Participants: 12 · Started: Jan 16, 2026
Contact the study team
- Matias Costa, MD · Phone: 409-772-0330
- Patrick Karas, MD · Phone: 409-772-0330
Official record on ClinicalTrials.gov — NCT07402954
Locations in the U.S.
| Texas | University of Texas Medical Branch, Galveston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.