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Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

A Randomized Controlled Trial Comparing Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT) in Reducing Intraocular Pressure in Open-Angle Glaucoma

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥18 years
* Diagnosis of OAG (including exfoliative or pigmentary) or OHT
* Gonioscopically open angle (visible scleral spur 360°)
* Ability to consent and comply with follow-up

Exclusion Criteria:

* Angle-closure or secondary glaucomas
* IOP \>35 mmHg despite therapy
* Corneal pathology interfering with laser or IOP measurement
* Recent ocular surgery (\<6 months)
* Contraindications to study medications or procedures
* Cognitive impairment preventing consent

About the study

This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.

What is being tested

• Direct Selective laser Trabeculoplasty (device)

Sponsor: Medical University of South Carolina · Participants: 172 · Started: Apr 27, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07408154

Locations in the U.S.

Conditions

• Open-Angle Glaucoma
• Ocular Hypertension
• Glaucoma

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.