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Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* Bilateral STN or GPi DBS with Boston Scientific Vercise Genus DBS System
* Diagnosis of Parkinson's disease as confirmed by a movement disorders fellowship trained neurologist
* Chronic stable DBS therapy, defined as having DBS therapy for at least 6 months

Exclusion Criteria:

* History of previous neurosurgical intervention aside from DBS
* Diagnosis of dementia (whether primary or related to Parkinson's disease)
* A diagnosis of atypical parkinsonism or secondary parkinsonism at any time after DBS implantation

About the study

The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have had stable bilateral Subthalamic Nucleus (STN) and Globus Pallidus internus (GPi) DBS.

What is being tested

• Biphasic deep brain stimulation (device)
• Conventional deep brain stimulation (device)
• Theta burst deep brain stimulation (device)
• Multi frequency deep brain stimulation (device)

Sponsor: University of Florida · Participants: 60 · Started: May 6, 2026

Contact the study team

• Joshua Wong, MD · Phone: 352-294-5400

Official record on ClinicalTrials.gov — NCT07410598

Locations in the U.S.

Conditions

• Parkinson's Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.