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Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

Feasibility of Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly (≤10 Cigarettes Per Day) or Non-daily

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥18
* Able to read and understand English or Spanish
* Smoke 1-10 cigarettes/day on at least 4 days of the past two weeks for the last year
* Willing to try quitting in next 30 days
* Access to cell phone with texting capabilities

Exclusion Criteria:

* Current participation in another smoking cessation study
* Unable to provide consent
* Refusal to abstain from e-cigarettes or other tobacco products
* Use of medications affecting smoking cessation (e.g., Chantix, Wellbutrin)

About the study

This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily. Secondary objectives include assessing preliminary efficacy on cessation and examining cue reactivity. Participants will be randomized to CBT only or CBT + cue-based treatment, with assessments at baseline, end-of-treatment, 6 months, and 12 months.

What is being tested

• Cognitive Behavioral Therapy (CBT) (behavioral)
• Cue-based treatment intervention (behavioral)

Sponsor: Duke University · Participants: 60 · Started: Jul 7, 2026

Contact the study team

• Laura Fish, PhD · Phone: 919-681-3820
• Lauren Hart, MSW, MPH · Phone: 919-613-2607

Official record on ClinicalTrials.gov — NCT07425119

Locations in the U.S.

Conditions

• Quitting Smoking (Tobacco Use Disorder)
• Quitting Smoking

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.