Home › Overweight › NCT07428187
Snacking Effects on the Brain Response to Foods and Satiety During Dieting
Recruiting
Who can join
Ages 25 to 45 · All sexes
Full eligibility criteria
Inclusion Criteria: * 25-45 years old * BMI at least 27 kg/m2 * Comfortable completing a weight-loss intervention\\ * Willing to consume a daily snack of either walnuts or pretzels Exclusion Criteria: * Nut or wheat allergy * History of bariatric surgery * Current eating disorder * Current illicit substance use * Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum * Uncontrolled hypertension (\>160/100 mmHg) * Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results * Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment * Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists) * Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns) * Neurological illnesses or injury that would be anticipated to affect MRI data * Weight change greater than 10% within 3 months prior to study participation * Currently participating in another weight-loss study * Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan) * MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs
About the study
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
What is being tested
- Snack Type 1: Walnuts (other)
- Snack Type 2: Pretzels (other)
Sponsor: University of Colorado, Denver · Participants: 70 · Started: Mar 5, 2026
Contact the study team
- Allison Hild, BS · Phone: 3037249024
- Kristina T Legget, PhD · Phone: 303-724-5809
Official record on ClinicalTrials.gov — NCT07428187
Locations in the U.S.
| Colorado | University of Colorado Anschutz Medical Campus, Aurora |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.