Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

Inclusion Criteria:

* Clinical diagnosis of Parkinson's disease
* Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD
* Clinically optimized DBS parameters for one month prior to enrollment
* Ability to ambulate with or without an assistive device for 5 continuous minutes
* Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments

Exclusion Criteria:

* Neurocognitive impairment that compromises the ability to provide informed consent
* Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)
* Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen:

  1. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provided prior to participation.
  2. Those who choose not to obtain physician clearance will not be eligible for participation. Those who do not receive physician clearance for high intensity exercise will not be eligible.
* A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise
* Current cardiac arrhythmia