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SickleFit Exercise and Nutrition Study

The SickleFit Exercise and Nutrition Randomized Control Trial for Older Adults With Sickle Cell Disease

Who can join

Ages 35 and older · All sexes

Inclusion Criteria:

* Laboratory-confirmed diagnosis of sickle cell disease (any genotype)
* Understand and speak English by self-report
* Age ≥ 35 years old

Exclusion Criteria:

* Oxygen dependence
* Unstable cardiac disease
* Wheelchair-bound
* Diagnosed with severe cognitive impairment based on ICD-10 codes or reported by their outpatient provider
* Unable to self-consent
* Severe uncorrected visual or auditory impairment
* Pregnant
* Successfully treated with hematopoietic stem cell transplantation or gene therapy for sickle cell disease

About the study

To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial

What is being tested

• SickleFit Exercise plus Nutrition (behavioral)

Sponsor: Duke University · Participants: 40 · Started: Apr 8, 2026

Contact the study team

• Teagan Callaway · Phone: 919-684-0628

Official record on ClinicalTrials.gov — NCT07442851

Locations in the U.S.

Conditions

• Sickle Cell Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.