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Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

Phase 1B/2A Study of the Safety and Tolerability of Human Neural Stem Cells for Huntington's Disease

Who can join

Ages 18 to 65 · All sexes

Please note this may not be a complete list of eligibility criteria.

Inclusion Criteria:

* Have decision-making capacity and be able to provide written informed consent.
* Are between 18 to 65 years of age
* Have genetically confirmed diagnosis of Huntington's Disease
* Able to undergo MRI scans, tolerate neurosurgical procedure, blood draws and lumbar puncture.

Exclusion Criteria:

* Are pregnant
* Test positive for human immunodeficiency virus (HIV), hepatitis C or chronic hepatitis B at Screening
* Have an implanted deep brain stimulation device.

About the study

The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.

What is being tested

• hNSC-01 (biological)

Sponsor: Leslie Thompson · Participants: 21 · Started: Apr 6, 2026

Contact the study team

• UCI Alpha Clinic · Phone: 949-824-3990

Official record on ClinicalTrials.gov — NCT07451613

Locations in the U.S.

Conditions

• Huntington's Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.