Home › Knee Osteoarthritis › NCT07472088

Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥ 18
* Knee pain, falling into either of the two groups, i.e., PFJ pain (pain only in the anterior region of the knee) or symptomatic knee OA (pain in any other area of the knee, including the anterior region)

Exclusion Criteria:

* Bilateral total knee arthroplasty
* Pregnant
* Unable to stand safely for 2 minutes with support
* Any condition that the investigator identifies as inappropriate for participation (e.g., unable to participant in consent process, unsafe to stand on WBCT platform, etc.)

About the study

Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called "runner's knee". It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stairs, or kneeling painful.

Symptomatic knee osteoarthritis (OA) is a common, long-term condition where the protective cartilage in the knee joint wears away, causing the bones to rub together, leading to daily pain and stiffness. In simple terms, it is a "wear-and-tear" disease of the entire joint that makes walking, climbing stairs, or bending the knee difficult.

The PFJ is where the patella (kneecap) meets the femoral trochlea (front part of the lower thigh bone) at the front of the knee. Patellar tracking refers to the movement of the patella that begins to engage in the distal femoral trochlear groove (smooth, U-shaped groove at the bottom of the thigh bone).

By doing this study, we hope to advance clinical knowledge of the PTJ features in a more natural position by using weight-bearing computed tomography (WBCT) images while the leg is straight and slightly bent. Determining links between specific knee symptoms and the PTJ structure on WBCT images could enable providers to effectively target the underlying causes and to develop targeted treatments.

What is being tested

• WBCT (radiation)

Sponsor: University of Kansas Medical Center · Participants: 36 · Started: Apr 29, 2026

Contact the study team

• Jessica Lee, PhD · Phone: 913-574-0961

Official record on ClinicalTrials.gov — NCT07472088

Locations in the U.S.

Conditions

• Knee Osteoarthritis
• Patellofemoral Pain Syndrome

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.