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EMS-Initiated Buprenorphine

Emergency Medical Services (EMS)-Initiated Buprenorphine

Who can join

All ages · All sexes

Inclusion Criteria:

* 18 years of age or older
* Treated by the EMS-Initiated buprenorphine clinical protocol which includes:

Patients that accept EMS-Initiated BUP protocol. Patients offered the EMS-Initiated BUP protocol but declined.1

* Willing to follow study procedures.
* Able to speak English sufficiently to understand study procedures, and to provide verbal and electronic/written consent.

Exclusion Criteria:

* Patients who lack decision making capacity
* Patients who are in police or protective custody

About the study

This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm prospective trial that will provide preliminary effectiveness data, from which to build a larger randomized control trail (RCT) trial.

Sponsor: Yale University · Participants: 495 · Started: May 21, 2026

Contact the study team

• Gail D'Onofrio, MD, MS · Phone: 12037857059

Official record on ClinicalTrials.gov — NCT07475728

Locations in the U.S.

Conditions

• Opioid Overdose

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.