Microbiome-targeted Diet Therapy in Ulcerative Colitis

Inclusion Criteria:

* Ability and willingness to provide informed consent
* Age at least 18 years old
* Diagnosis of UC based on clinical and endoscopic criteria
* UC duration of at least 3 months
* Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score ≤4 within 90 days of randomization
* On a stable dose or no existing UC therapies (apart from steroids) for defined periods (as outlined below).

  1. ≥4 weeks if no medication, 5-ASA
  2. ≥8 wk for immunomodulatory therapy
  3. ≥12 wk for biologics
* Ability to comply with study requirements in the opinion of the primary investigator

Exclusion Criteria:

* Moderate or severe UC as defined by UCEIS ≥5
* History of stomach surgery or bowel resection
* Antibiotic use within 3 months
* Anticipated antibiotic exposure during the study period (e.g. perioperative antibiotics)
* Pregnancy or breastfeeding
* History of anaphylactic food allergies
* Intolerance of high dietary fiber content
* Ongoing alcohol or drug abuse
* Habitual vegan diet pattern
* Insufficient freezer space to accommodate meal delivery