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Ulcerative Colitis clinical trials recruiting in the U.S.
77 studies for Ulcerative Colitis are recruiting participants at sites across the United States.
Ulcerative Colitis (UC) can cause long-lasting swelling and ulcers in the large intestine. It is a type of inflammatory bowel disease. Find out more.
Cities with the most studies
- Orlando, FL21 studies
- New York City, NY21 studies
- Miami, FL20 studies
- Houston, TX14 studies
- San Diego, CA13 studies
- Chicago, IL13 studies
- Tacoma, WA13 studies
- St. Louis, MO13 studies
- Tyler, TX13 studies
- San Antonio, TX13 studies
- Colorado Springs, CO12 studies
- Boston, MA12 studies
- Los Angeles, CA11 studies
- Washington, DC10 studies
- Providence, RI10 studies
- Parma, OH9 studies
- Memphis, TN9 studies
- Evanston, IL9 studies
- Lubbock, TX9 studies
- Atlanta, GA9 studies
- Louisville, KY9 studies
- Cincinnati, OH8 studies
- Durham, NC8 studies
- Scottsdale, AZ8 studies
- Round Rock, TX8 studies
- Lewisville, TX8 studies
- Waukegan, IL8 studies
- Garland, TX8 studies
- Cleveland, OH8 studies
- Fort Worth, TX8 studies
- Pittsburgh, PA7 studies
- Richmond, VA7 studies
- Dayton, OH7 studies
- Metairie, LA7 studies
- Seattle, WA7 studies
- Tampa, FL7 studies
- League City, TX7 studies
- Baltimore, MD7 studies
- Charlotte, NC6 studies
- Dallas, TX6 studies
By state
- Alabama6 studies
- Arizona17 studies
- Arkansas3 studies
- California36 studies
- Colorado15 studies
- Connecticut9 studies
- District of Columbia3 studies
- Florida29 studies
- Georgia13 studies
- Idaho5 studies
- Illinois23 studies
- Indiana11 studies
- Kansas8 studies
- Kentucky12 studies
- Louisiana12 studies
- Maryland11 studies
- Massachusetts18 studies
- Michigan14 studies
- Minnesota7 studies
- Mississippi6 studies
- Missouri17 studies
- Nevada6 studies
- New Hampshire5 studies
- New Jersey8 studies
- New York28 studies
- North Carolina21 studies
- Ohio24 studies
- Oklahoma4 studies
- Oregon4 studies
- Pennsylvania12 studies
- Rhode Island10 studies
- South Carolina14 studies
- South Dakota3 studies
- Tennessee13 studies
- Texas30 studies
- Utah5 studies
- Virginia14 studies
- Washington19 studies
- Wisconsin5 studies
Recently updated studies
A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 12, 2026 · NCT07845487Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04751396Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03816345A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 12, 2026 · NCT07463183A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06636656Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
RecruitingPhase 3
All ages · All sexes · Updated Nov 10, 2026 · NCT06651281Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease
RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT07619547Microbiome-targeted Diet Therapy in Ulcerative Colitis
Recruiting
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07520461LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07415044A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07483073Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Nov 4, 2026 · NCT06937086LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07186101Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study)
RecruitingPhase 1/2
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07913347A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
RecruitingPhase 3
Ages 3 and older · All sexes · Updated Nov 3, 2026 · NCT06663332A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
RecruitingPhase 4
Ages 18 and older · Women · Updated Nov 3, 2026 · NCT07654751A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07577856A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT04372108Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 2, 2026 · NCT07501078ALPCO Calprotectin CLIA Assay - Measurement of Calprotectin Levels in Human Stool
RecruitingObservational studyHealthy volunteers welcome
Ages 22 and older · All sexes · Updated Oct 30, 2026 · NCT06810518Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Oct 30, 2026 · NCT06619990A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Oct 28, 2026 · NCT06581328A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06979336Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 27, 2026 · NCT07697456A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
RecruitingPhase 2
Ages 12 to 17 · All sexes · Updated Oct 27, 2026 · NCT05287126A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 27, 2026 · NCT07012395From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.