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Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.

Rise & Thrive: Community-Engagement Intervention to Address Chronic Stress and Prevent Depression in Adolescents and Young Adults

Who can join

Ages 15 to 20 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. 15-20 years old
2. Identify as Black and/ or Hispanic/Latine
3. Speak English

Exclusion Criteria:

1. Younger than 15 years old, or older than 20 years old
2. Unable to attend the in-person sessions
3. Non-fluent English speaker
4. Do not identify as Black or Hispanic/Latine

About the study

American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States. Four in 10 American high school students experience chronic feelings of sadness and hopelessness, 2 in 10 report suicidal ideation, and 1 in 10 attempt suicide. For adolescents and young adults, chronic stress translates to weathering, or wear and tear on the mind and body. Chronic stress in youth contributes to psychological distress, elevated allostatic load, and an elevated risk for chronic diseases and premature death. While the connection between chronic stress and health is well documented, few studies provide evidence on innovative, non-medication strategies to reduce stress and mitigate the consequences of chronic stress on psychological and physiological outcomes. Thus, there is a critical need to rigorously test interventions that prevent the negative influence of chronic stress on mental and physical health, beginning in adolescence. The specific aims of the study are to 1) Determine whether a community-engagement, peer-based behavioral intervention reduces depressive symptoms in adolescents and young adults, 2) Determine whether a community-engagement behavioral intervention lowers allostatic load scores in adolescents and young adults, and 3) Identify factors that help sustain or inhibit community-engagement and intervention effects for adolescents and young adults. To accomplish these aims, the team will conduct a phase II community-engaged, peer group-based, multi-component randomized behavioral clinical trial. We will collect psychological and physiological measures at baseline, then at 6-month intervals for 2 years post-community-engaged, skills training.

What is being tested

• Rise Together: Community Engagement Intervention (behavioral)
• Adulting 101: Life Skills (behavioral)

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago · Participants: 300 · Started: Jun 9, 2026

Contact the study team

• Nia J Heard Garris, MD, MBA, MSc · Phone: 3122272664
• Akram Ibrahim, MS · Phone: 312-227-6944

Official record on ClinicalTrials.gov — NCT07554326

Locations in the U.S.

Conditions

• Depression
• Metabolic Syndrome

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.