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BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease

Recruiting

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Both mothers and infants are study participants.

Inclusion criteria:

1. Pregnant individual carrying a fetus diagnosed with CHD or biological mother of an infant diagnosed with CHD in the neonatal period.
2. Fetus or newborn with CHD anticipated to require cardiac surgery or transcatheter intervention in the first 30 days of life.
3. Admission to the ICU (either CICU or NICU) at participating center in 1st week of life and for whom cardiac surgical or transcatheter intervention is anticipated in the first 30 days of life.
4. Willing to comply with protocol and provide written informed consent

Exclusion Criteria:

1. Mother, fetal, or infant medical condition determined by a treating clinician to be contraindicative to study participation.
2. Mother with a severe, untreated psychiatric condition, substance use disorder, or other circumstances that, in the opinion of the investigator, would interfere with engagement with study tasks or safe participation in the trial.
3. Mother with a moderate to severe intellectual disability or is otherwise unable to provide informed consent.
4. Infant birthweight \<3rd percentile for gestational age
5. Infant gestational age \< 36 weeks
6. Infant with known genetic disorder likely to impact breastfeeding, such as trisomy 21 or cleft palate
7. Medical condition or congenital anomaly that precludes safe direct breastfeeding for the infant as determined by investigator

About the study

The primary objective of this study is to enhance the rates of direct breast feeding (DBF) among infants with congenital heart disease (CHD), and to gain insights into the implications of DBF on key metrics of child and parent well-being. A multicenter parallel cluster platform design will be employed. The intervention will be a multifaceted approach to enhance direct breastfeeding. Participating sites will be randomized into either intervention (strategies to enhance direct breastfeeding) or conventional care.

What is being tested

Sponsor: Carelon Research · Participants: 266 · Started: Jul 22, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07582848

Locations in the U.S.

ArizonaPhoenix Children's Hospital, Phoenix (Not yet recruiting)
CaliforniaChildren's Hospital of Los Angeles, Los Angeles (Not yet recruiting)
ColoradoChildren's Hospital Colorado, Aurora (Not yet recruiting)
GeorgiaChildren's Healthcare of Atlanta, Atlanta
IllinoisLurie Children's Hospital, Chicago (Not yet recruiting)
KentuckyGolisano Children's at UK, Lexington (Not yet recruiting)
MassachusettsBoston Children's Hospital, Boston (Not yet recruiting)
MichiganUniversity of Michigan Health System, Ann Arbor, Ann Arbor
MissouriChildren's Mercy Hospital, Kansas City (Not yet recruiting)
Washington University School of Medicine, St Louis (Not yet recruiting)
New YorkChildren's Hospital of New York, New York (Not yet recruiting)
Icahn School of Medicine at Mount Sinai, New York (Not yet recruiting)
OhioCincinnati Children's Hospital Medical Center, Cincinnati
PennsylvaniaUniversity of Pittsburgh Medical Center, Pittsburgh (Not yet recruiting)
South CarolinaMedical University of South Carolina, Charleston
TennesseeLe Bonheur Children's Hospital, Memphis
UtahPrimary Children's Medical Center, Salt Lake City (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.