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Spasticity in SCI Following Acute Intermittent Hypoxia

Recruiting

Does the Administration of Acute Intermittent Hypoxia in Persons With Chronic Spinal Cord Injury Make Spasticity Worse?

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Age \>= 18
* Non-progressive spinal Cord injury at least 6 months prior
* Level of injury between C1-C8
* ISNCSCI ASIA classification C or D
* Measurable Spasticity

Exclusion Criteria:

* Pre-existing hypoxic pulmonary disease
* Positive Covid-Pneumonia diagnosis within 1 year of visit
* Uncontrolled hypertension \>140/90 mmHg
* Individuals who are currently pregnant/nursing or planning on becoming pregnant
* Individuals with a tracheostomy or who utilize mechanical ventilation
* A botulinum toxin injection to upper extremity musculature within the past 3 months
* Currently taking Baclofen
* Congestive Heart Failure
* Cardiac arrhythmias
* Uncontrolled diabetes mellitus
* Chronic obstructive pulmonary disease
* Emphysema
* Severe Asthma
* Previous myocardial infarction
* Carotid/intracerebral artery stenosis
* Orthopedic injuries or surgeries that impact the ability to use the upper extremity
* History of Epilepsy

About the study

This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.

What is being tested

Sponsor: Zev Rymer · Participants: 10 · Started: Mar 17, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07583498

Locations in the U.S.

IllinoisShirley Ryan AbilityLab, Chicago

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.