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Connectomic Alterations Following Acute Ischemic Stroke in the MCA Territory

Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory: A Pilot Study of Prognostic Value and Structural Disruption

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age \> 18 years;
* Diagnosis of acute ischemic stroke with confirmed occlusion of the M1 or more distal MCA territory.
* Received reperfusion therapy via mechanical thrombectomy or IV thrombolytics(Tenecteplase, or Alteplase).
* Presence of a motor deficit on initial clinical exam (e.g., NIHSS \> 0) and on immediate post-intervention exam.
* Patients or health-care proxy must be able to provide informed consent.
* Must be able to undergo sequential MRI at Lenox Hill Hospital, including resting-state fMRI (rs-fMRI) and diffusion MRI (dMRI) for, respectively, functional, and structural connectomic analyses.

Exclusion Criteria:

* Age \< 17 years;
* Large vessel occlusions proximal to M1 (e.g., ICA), completed M1 occlusions.
* Pre-stroke Modified Rankin Scale score ≥ 3
* Known neurodegenerative disease or prior stroke affecting motor pathways.
* Inability to undergo MRI due to cardiac pacemaker, claustrophobia, and metal implants that cannot be removed prior to MRI.
* Pregnancy. Because of potential risk of serial MRI to fetus, women of child-bearing age require a pregnancy test at screening and agree to contraceptive practices during the study.
* Poor image quality or incomplete imaging datasets.

About the study

This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections. Using structural MRI, including diffusion-weighted imaging, this study will generate a detailed map of brain pathways to evaluate how strokes in the middle cerebral artery (MCA) territory disrupt the brain's structural networks. In the future, this approach may help physicians better predict recovery, monitor neuroplasticity, and guide rehabilitation decisions after stroke.

What is being tested

• MRI with connectomic sequencing (other)

Sponsor: Northwell Health · Participants: 10 · Started: May 19, 2026

Contact the study team

• Tamika Wong, MPH · Phone: (212) 434-4836

Official record on ClinicalTrials.gov — NCT07584681

Locations in the U.S.

Conditions

• Ischemic Stroke

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.