Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases.

80 patients with confirmed metastatic tumor (\>2.5 cm in short axis) will be enrolled, all ≥ 12 years of age with ECOG ≤ 2. All genders and races will be included.

Inclusion Criteria:

* Histologically, cytologically, or radiographically confirmed diagnosis of metastatic cancer
* One to two metastases in non-brain sites that are amenable to LATTICE radiotherapy: \>2.5 cm in short axis (dimension on axial imaging that is perpendicular to the longest dimension); bone metastasis can be included if the extraosseous component is \>2.5 cm in short axis
* Age ≥12
* ECOG Performance Status 0-2
* For patients age 12-16, Lansky Play-Performance score 50-100
* Negative serum or urine pregnancy test within 2 weeks prior to enrollment of people of childbearing potential
* All patients and/or their parents or legal guardians must sign a written informed consent. For any child less than 18 years of age, assent must also be obtained in addition to parental or legal guardian consent.

Exclusion criteria:

* Prior radiation therapy to the tumor to be treated
* Active pregnancy
* Diseases that place the patient at high risk of radiation complications including lupus, scleroderma, Li Fraumeni syndrome
* The tumor to be treated is from a hematologic malignancy such as lymphoma or myeloma