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Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Who can join

Ages 18 to 50 · Women

Inclusion Criteria:

* mothers with diagnosis of Opioid Use Disorder (OUD); and/or receiving medication assisted treatment (such as buprenorphine or methadone)
* with a child aged 5 or less
* able to read, hear and understand English adequately enough to provide informed consent

Exclusion Criteria:

* require immediate clinical care for suicidal/homicidal risk or psychosis;
* For magnetic resonance imaging (MRI) of the brain, potential participants will be excluded if they: (1) have ferromagnetic metal in their heads (2) have severe claustrophobia that prevents participation in the neuroimaging (3) have serious neurological condition that could interfere with neuroimaging, including a brain tumor, multiple sclerosis or significant head trauma

About the study

Having met the milestones of the R61, this R33 is a 2-site, 2-group, pre/post RCT of mothers with OUD (n=\~80/group). We will test whether the beneficial pre-post changes in OUD mothers randomized to vMP exceed those of mothers assigned to Enhanced Usual Care (EUC) and via changes in Maternal Brain Neurocircuits.

What is being tested

• Mom Power (behavioral)

Sponsor: Stony Brook University · Participants: 80 · Started: Jul 1, 2025

Contact the study team

• James E Swain, MD, PhD · Phone: 516-838-7604
• Maria Muzik, MD, MSc · Phone: 734-846-8027

Official record on ClinicalTrials.gov — NCT07632053

Locations in the U.S.

Conditions

• Opioid Overdose

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.