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Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment

Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment (VR-MCI)

Who can join

Ages 55 to 90 · All sexes

Inclusion Criteria:

* Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD)
* Capacity to provide informed consent
* Able to provide own transportation to sessions
* Speaks and understands English
* Ambulatory

Exclusion Criteria:

* Uncontrolled seizures or epilepsy
* Severe psychiatric illness or active suicidality
* Inability to follow instructions or tolerate VR (severe motion sickness)
* Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.)
* Any condition that the research team determines would interfere with safe participation

About the study

The purpose of this study is to demonstrate feasibility, usability, and acceptability of virtual reality (VR)-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes.

What is being tested

• Virtual Reality (VR) sessions (device)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 10 · Started: Jun 18, 2026

Contact the study team

• Seema S Aggarwal, PhD, APRN, AGNP-C · Phone: (713) 500-9946
• Tela Todd · Phone: (713) 500-7039

Official record on ClinicalTrials.gov — NCT07638748

Locations in the U.S.

Conditions

• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.