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Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With Fibromyalgia

Transcranial Electrical Stimulation for Noninvasive Study of Pain Circuits in Patients With Chronic Pain

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

* Formal diagnosis of fibromyalgia made by a practicing physician
* Pain resistant to common analgesics and medications for chronic pain
* Existing pain for more than 3 months with an average of at least 4 on a 0 to 10 Numerical Rating Scale (NRS)
* Females of child bearing potential must be at least one of the following totally abstinent from heterosexual intercourse since the last menses before start of study, or agree to concurrent use of at least two methods of birth control throughout study participation.

Exclusion Criteria:

* If the subject is non-ambulatory.
* If the subject is female of child-bearing potential, subject must not be pregnant.
* Subject must not have a history of brain surgery or uncontrolled neurological conditions, such as seizure, fainting spells, transient ischemic attack.
* Subject must not have lifetime history of severe, uncontrolled mood disorders (anxiety, depression, bipolar), psychotic disorders, other neural disorders, or heart disease.
* Subject must not have any implanted electronic or metallic devices.
* Subject must not have heart diseases, including known arrhythmia, or severe liver or severe gastrointestinal disease or chronic severe infectious disease (e.g. HIV/AIDS).

About the study

The goal of this interventional study is to learn whether noninvasive brain stimulation (NIBS) will have an effect on pain perception in people with fibromyalgia. The main questions it aims to answer are:

Do repeated sessions of NIBS lead to a reduction in perceived pain? Do repeated sessions of NIBS lead to an improvement in quality of life?

Researchers will compare different brain targets to see if effects are different between them.

Participants will receive repeated daily sessions of NIBS over 4 weeks with application of pressure pain algometry, and complete various questionnaires.

What is being tested

• Primary Motor Cortex Stimulation (device)
• Occipital Lobe Stimulation (device)

Sponsor: Pulkit Grover · Participants: 50 · Started: Sep 9, 2026

Contact the study team

• Pulkit Grover, PhD · Phone: 412-268-3644
• Benedict J Alter, PhD · Phone: 412-677-0575

Official record on ClinicalTrials.gov — NCT07644221

Locations in the U.S.

Conditions

• Fibromyalgia
• Chronic Pain

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.