Targeted Early Detection Program in Men at High Genetic Risk for Prostate Cancer

Inclusion Criteria:

* \* Age 35-70 years

  * Capable of providing informed consent
  * Prognosis of \> 5 years if affected by another cancer
  * Patients need one to meet at least one of the following high genetic risk categories:

    * Known PCa-related mutations: BRCA 1 and 2, Lynch syndrome, or p53
    * Carrier of mutation in a suspected PCa-related gene: e.g., ATM, PALB2, CHEK2, RAD51D, ATR, NBN, GEN1, RAD51C, MRE11A, BRIP1, FAM175A, HOXB13
    * Obligate carriers of the above mutations (e.g. their sisters/daughters have known mutations)
    * Men with any family history of above mutation
    * Family history of breast, prostate, or ovarian cancer in at least 2 individuals, or in 1 individual diagnosed before age 50

Exclusion Criteria:

* \* Anuria

  * Prior diagnosis or treatment for PCa
  * Failure to provide informed consent
  * Life expectancy \< 5 years