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A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication(s) * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Increased risk of cardiovascular (CV) events defined by ≥1 of: documented coronary heart disease, peripheral arterial disease, ischemic cerebrovascular disease, or heart failure (NYHA II-III); or ≥2 CV risk factors * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM), secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper Gastrointestinal (GI) tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (NYHA IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
About the study
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
What is being tested
- Elecoglipron (drug)
- Semaglutide (drug)
Sponsor: AstraZeneca · Participants: 1,200 · Started: Jul 6, 2026
Contact the study team
- AstraZeneca Clinical Study Information Center · Phone: 1-877-240-9479
Official record on ClinicalTrials.gov — NCT07662213
Locations in the U.S.
| Alabama | Research Site, Birmingham (Not yet recruiting) |
| Arizona | Research Site, Mesa (Not yet recruiting) Research Site, Phoenix (Not yet recruiting) Research Site, Tempe (Not yet recruiting) |
| California | Research Site, Covina (Not yet recruiting) Research Site, Encinitas (Not yet recruiting) Research Site, Garden Grove (Not yet recruiting) Research Site, Loma Linda (Not yet recruiting) Research Site, Long Beach (Not yet recruiting) Research Site, Pomona (Not yet recruiting) Research Site, Sacramento (Not yet recruiting) |
| Connecticut | Research Site, Bridgeport (Not yet recruiting) |
| Florida | Research Site, Crystal River (Not yet recruiting) Research Site, Hollywood (Not yet recruiting) Research Site, Jacksonville (Not yet recruiting) Research Site, Lake City (Not yet recruiting) Research Site, Leesburg (Not yet recruiting) Research Site, Orlando (Not yet recruiting) |
| Georgia | Research Site, Lilburn (Not yet recruiting) |
| Idaho | Research Site, Idaho Falls (Not yet recruiting) |
| Illinois | Research Site, Melrose Park (Not yet recruiting) |
| Indiana | Research Site, Evansville (Not yet recruiting) |
| Iowa | Research Site, Ames (Not yet recruiting) |
| Kansas | Research Site, Wichita (Not yet recruiting) |
| Kentucky | Research Site, Bowling Green (Not yet recruiting) |
| Maryland | Research Site, Rockville (Not yet recruiting) |
| Michigan | Research Site, Southfield (Not yet recruiting) |
| Minnesota | Research Site, Minneapolis (Not yet recruiting) |
| Missouri | Research Site, Jefferson City (Not yet recruiting) Research Site, Kansas City (Not yet recruiting) |
| Nebraska | Research Site, Omaha (Not yet recruiting) |
| Nevada | Research Site, Henderson (Not yet recruiting) Research Site, Las Vegas (Not yet recruiting) |
| New Mexico | Research Site, Albuquerque (Not yet recruiting) |
| North Carolina | Research Site, Durham (Not yet recruiting) Research Site, Morehead City (Not yet recruiting) Research Site, Raleigh (Not yet recruiting) Research Site, Statesville (Not yet recruiting) Research Site, Wilmington (Not yet recruiting) |
| Ohio | Research Site, Columbus (Not yet recruiting) |
| Oklahoma | Research Site, Oklahoma City (Not yet recruiting) |
| Pennsylvania | Research Site, Feasterville-Trevose (Not yet recruiting) Research Site, Philadelphia (Not yet recruiting) |
| South Carolina | Research Site, Myrtle Beach (Not yet recruiting) Research Site, North Charleston (Not yet recruiting) |
| Tennessee | Research Site, Memphis (Not yet recruiting) Research Site, Morristown (Not yet recruiting) |
| Texas | Research Site, Dallas (Not yet recruiting) Research Site, Houston (Not yet recruiting) Research Site, Houston (Not yet recruiting) Research Site, Houston (Not yet recruiting) Research Site, Katy (Not yet recruiting) Research Site, San Antonio (Not yet recruiting) Research Site, San Antonio (Not yet recruiting) Research Site, Sugar Land (Not yet recruiting) Research Site, Weslaco (Not yet recruiting) |
| Utah | Research Site, Bountiful (Not yet recruiting) Research Site, Salt Lake City (Not yet recruiting) |
| Virginia | Research Site, Leesburg (Not yet recruiting) Research Site, Norfolk (Not yet recruiting) |
| Washington | Research Site, Renton (Not yet recruiting) Research Site, Seattle (Not yet recruiting) Research Site, Seattle (Not yet recruiting) |
| West Virginia | Research Site, Morgantown (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.