🔎 Trials Near Me

Home › Type 2 Diabetes › NCT07668388

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

RecruitingPhase 2

Efficacy and Safety of Once-weekly Subcutaneous UBT251 in Participants With Type 2 Diabetes - a Dose-finding Study

Who can join

Ages 18 to 75 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Male or female (sex assigned at birth, inclusive of all gender identities).
* Age 18-75 years (both inclusive) at the time of signing the informed consent.
* Diagnosed with type 2 diabetes greater than or equal to (≥) 180 days before screening.
* Stable daily dose(s) ≥ 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator:

metformin with or without sodium-glucose cotransporter-2 (SGLT2) inhibitor.

* HbA1c of 7.0-10.5 percent (%) (53-91 millimoles per mole (mmol/mol)) (both inclusive) as assessed by central laboratory at screening.
* Body mass index between 25.0 kg/m\^2 and 50.0 kg/m\^2 (both inclusive) at screening.

Exclusion Criteria:

* Treatment with any medication (prescription or over-the counter) or alternative remedies for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed.
* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
* Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire, question 8.

About the study

The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.

What is being tested

Sponsor: Novo Nordisk A/S · Participants: 300 · Started: Jun 22, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07668388

Locations in the U.S.

AlabamaFlourish Research, Birmingham
CaliforniaArk Clinical Research, Fountain Valley
Ark Clinical Research, Long Beach
Los Angeles Institute for Metabolic Research, Los Angeles
Catalina Research Institute, LLC, Montclair
FloridaEncore Medical Research LLC, Hollywood
South Broward Research LLC, Miramar
Encore Medical Research of Weston, Weston
IndianaMidwest Inst For Clin Res, Indianapolis (Not yet recruiting)
KansasCotton O'Neil Diabetes & Endocrinology, Topeka
MarylandMD Medical Research, Oxon Hill
North CarolinaPharmQuest, Greensboro (Not yet recruiting)
KDCILM, LLC & Accellacare US, Inc., Wilmington
North DakotaPlains Clinical Research Center, LLC_Fargo, Fargo (Not yet recruiting)
PennsylvaniaPreferred Primary Care Physicians, Inc., Uniontown
South CarolinaMonroe Biomedical Research, LLC, North Charleston
TennesseeLifeDoc Health, Memphis
TexasIMA Clinical Research, Austin
Private Practice - Dr. Laila A. Hassan, Houston
Radiance Clinical Research, Lampasas
Quality Research Inc, San Antonio
Tekton Research Inc, San Antonio
Consano Clin Res-Shavano Park, Shavano Park
UtahChrysalis Clinical Research, St. George
WashingtonThe Vancouver Clinic, Vancouver (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.