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A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
RecruitingPhase 3
Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria:
* Male or female (sex at birth).
* Age 18 years or above at the time of signing the informed consent.
Exclusion Criteria:
* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.
About the study
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
What is being tested
- Zenagamtide (drug)
- Semaglutide (drug)
- Placebo (matched to semaglutide) (drug)
- Placebo (matched to zenagamtide) (drug)
Sponsor: Novo Nordisk A/S · Participants: 650 · Started: Sep 22, 2026
Contact the study team
Official record on ClinicalTrials.gov — NCT07668414
Locations in the U.S.
| California | First Valley Medical Group, Lancaster
Desert Oasis Healthcare, Palm Springs
Western University of Health Sciences, Pomona
Artemis Insitute for Clin Res, San Diego |
| District of Columbia | Med Home Development Grp, Washington D.C. |
| Florida | Encore Medical Research LLC, Hollywood
NextPhase Research, Hollywood
Jacksonville Ctr Clin Res, Jacksonville (Not yet recruiting)
PharmaDev Clinical Research Institute LLC, Miami
South Broward Research LLC, Miramar
Essence MD Research, Naples (Not yet recruiting)
Florida Inst For Clin Res LLC, Orlando
Oviedo Medical Research, LLC, Oviedo
Palm Beach Research Center, West Palm Beach
Encore Medical Research of Weston, Weston |
| Georgia | Conquest Research, Atlanta
Eastside Bariatric and Gen Surg, Snellville |
| Illinois | Chicago Research Center, Inc, Chicago (Not yet recruiting)
Endeavor Health, Skokie |
| Indiana | Midwest Inst For Clin Res, Indianapolis |
| Louisiana | Southern Clin Research, Zachary (Not yet recruiting) |
| Missouri | Amicis Centers of Clinical Research, St Louis |
| New York | Ichor Research, Syracuse
Southgate Medical Group, LLP, West Seneca |
| North Carolina | PharmQuest Life Sciences LLC, Greensboro (Not yet recruiting)
Piedmont Healthcare/Research, Statesville |
| North Dakota | Lillestol Research LLC, Fargo |
| Pennsylvania | Geisinger Clinic, Danville |
| South Carolina | Medical University Of South Carolina, Charleston
Hillcrest Clinical Research, Simpsonville
Spartanburg Medical Research, Spartanburg |
| Texas | Amarillo Med Spec LLP, Amarillo
Texas Diabetes & Endocrinology, Austin
Pinnacle Clinical Research, Brownsville
Osvaldo A. Brusco MD, Corpus Christi
UT Southwestern Med Center, Dallas (Not yet recruiting)
Epic Medical Research, DeSoto (Not yet recruiting)
Houston Research Institute, Houston (Not yet recruiting)
The Endocrine Center, Houston (Not yet recruiting)
Sleep Therapy Research Center, San Antonio (Not yet recruiting)
Olympus Clinical Research, Sugar Land (Not yet recruiting) |
| Virginia | National Clin Res Inc., Richmond
Gastroent Consult of SW VA, Roanoke (Not yet recruiting) |
| Washington | Rainier Clin Res Ctr Inc, Renton
Seattle Clinical Research Center, Seattle |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.